James Cameron right now is on a real high and his next adventure will be the remake of the classic 1966 Sci Fi  adventure the Fantastic Voyage. This time in 3D

'Avatar' Director to Remake '60s Sci-Fi Classic

(Source and complete story at Cinemaspy.com)

It appears the Cameron-Salerno collaboration is going to be a 3-D remake of Fantastic Voyage, the science-fiction classic released in 1966. The original film concerned a small team attempting to save a nearly-assassinated diplomat’s life by being shrunk down and injected into the diplomat’s body. The team used a specialized submersible craft to travel up to the man’s brain to try and eradicate a blood clot.

Fun Fact.

Here is something I found in Wikipedia about the original

Fantastic Voyage is a 1966 science fiction film written by Harry Kleiner, based on a story by Otto Klement andJerome Bixby.Bantam Books obtained the rights for a paperback novelization based on the screenplay and approached Isaac Asimov to write it.Because the novelization was released six months before the movie, many people mistakenly believed Asimov's book had inspired the movie. According to Fred Schodt's The Astro Boy Essays, FOX also approached NBC to get the rights to an Astro Boy episode which had the same premise, but they never contacted the manga artist or credited him in the final product.

The movie inspired an animated television series, as well as a painting of the same name by Salvador Dalí.